The NFL season is heating up with an intriguing matchup on October 5, 2025, as the New England Patriots take on the Buffalo Bills at Highmark Stadium in Orchard Park, New York. The kickoff is scheduled for 8:20 PM.

Coming into this game, the New England Patriots hold a record of 2-2-0, placing them second in their division and eighth in the conference. They have managed to score 102 points while conceding 81, bringing their net point difference to 21.

On the other side, the Buffalo Bills are performing exceptionally well this season, leading their division and the conference with an undefeated record of 4-0-0. They have scored 133 points and allowed 90, resulting in a net point difference of 43.

Details for last week’s matchups are currently unavailable for both teams.

Jacoby Brissett, the quarterback for the Patriots, is set to lead his team again, while Josh Allen will be at the helm for the Bills.

Keep an eye on our site, betNewMexicosports.com, for continuous updates.

Betting Outlook:
Betting lines have the Buffalo Bills favored at home with a -9.70 point spread, while the Patriots are listed with an 11.00 point spread. The over/under for the game is set at 56.40. Moneyline odds are -502 for the Bills and +388 for the Patriots. These odds suggest expectations of a strong performance from Buffalo at home, making them the favored team to win, though the Patriots are anticipated to put up a formidable challenge.